KMID : 1102220180370010069
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Kidney Research and Clinical Practice 2018 Volume.37 No. 1 p.69 ~ p.76
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Effects of education on low-phosphate diet and phosphate binder intake to control serum phosphate among maintenance hemodialysis patients: A randomized controlled trial
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Lim Eun-Soo
Hyun Sun-Ah Lee Jae-Myeong Kim Sei-Rhan Lee Min-Jeong Lee Sun-Mi Oh Ye-Sung Park In-Whee Shin Gyu-Tae Kim Heung-Soo Morisky Donald E. Jeong Hyun-Jin
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Abstract
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Background: For phosphate control, patient education is essential due to the limited clearance of phosphate by dialysis. However, well-designed randomized controlled trials about dietary and phosphate binder education have been scarce.
Methods: We enrolled maintenance hemodialysis patients and randomized them into an education group (n = 48) or a control group (n = 22). We assessed the patients¡¯ drug compliance and their knowledge about the phosphate binder using a questionnaire.
Results: The primary goal was to increase the number of patients who reached a calcium-phosphorus product of lower than 55. In the education group, 36 (75.0%) patients achieved the primary goal, as compared with 16 (72.7%) in the control group (P = 0.430). The education increased the proportion of patients who properly took the phosphate binder (22.9% vs. 3.5%, P = 0.087), but not to statistical significance. Education did not affect the amount of dietary phosphate intake per body weight (education vs. control: -1.18 ¡¾ 3.54 vs. -0.88 ¡¾ 2.04 mg/kg, P = 0.851). However, the dietary phosphate-to-protein ratio tended to be lower in the education group (-0.64 ¡¾ 2.04 vs. 0.65 ¡¾ 3.55, P = 0.193). The education on phosphate restriction affected neither the Patient-Generated Subjective Global Assessment score (0.17 ¡¾ 4.58 vs. -0.86 ¡¾ 3.86, P = 0.363) nor the level of dietary protein intake (-0.03 ¡¾ 0.33 vs. -0.09 ¡¾ 0.18, P = 0.569).
Conclusion: Education did not affect the calcium-phosphate product. Education on the proper timing of phosphate binder intake and the dietary phosphate-to-protein ratio showed marginal efficacy.
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KEYWORD
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Compliance, Hemodialysis, Hyperphosphatemia, Phosphates
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